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Monkeypox virus protein H3L induces injuries in human and mouse

21 Aug 2024

Abstract excerpt

Monkeypox virus (MPV) is known to inflict injuries and, in some cases, lead to fatalities in humans. However, the underlying mechanisms responsible for its pathogenicity remain poorly understood. We investigated functions of MPV core proteins, H3L, A35R, A29L, and I1L, and discovered that H3L induced transcriptional perturbations and injuries. We substantiated that H3L upregulated IL1A expression. IL1A, in...

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PMID: 39168969
DOI: 10.1038/s41419-024-06990-2

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