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Article

Postprandial cardiac hypertrophy is sustained by mechanics, epigenetic, and metabolic reprogramming in pythons

19 Aug 2024

Abstract excerpt

Constricting pythons, known for their ability to consume infrequent, massive meals, exhibit rapid and reversible cardiac hypertrophy following feeding. Our primary goal was to investigate how python hearts achieve this adaptive response after feeding. Isolated myofibrils increased force after feeding without changes in sarcomere ultrastructure and without increasing energy cost. Ca 2+ transients were prolonged...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39159386
DOI: 10.1073/pnas.2322726121

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