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Integrating whole-genome resequencing data reveals adaptive selection signatures in sheep populations under extreme environments.

BMC genomics - 20 Nov 2025

Pang Zhixu, Yang Pengkun, Cai Ke, Wang Wannian, Afe Ayoola Ebenezer, Pan Yangyang, Qiao Liying, Liu Wenzhong

Abstract excerpt

Adaptation to extreme environments has shaped the genetic architecture of sheep, yet the genomic signatures remain insufficiently understood. This study aimed to uncover genomic regions and candidate genes mediating ovine adaptation to high-altitude, thermal, and arid environments. This study integrated whole-genome resequencing data from 444 individuals representing 91 native sheep populations with...

Topics

Animals
Selection, Genetic
Adaptation, Physiological
Sheep
Whole Genome Sequencing
Extreme Environments
Polymorphism, Single Nucleotide
Genomics

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 41266958
DOI: 10.1186/s12864-025-12281-7
PMCID: PMC12636215

Genes

BNC2
GHR
KCNMA1
MVD
PAPPA2
RXFP2
SLC26A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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