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Article

Real-world outcomes of atypical EGFR-mutated metastatic non-small cell lung cancer (mNSCLC)treated with osimertinib (osi) vs. Afatinib or erlotinib.

Lung cancer (Amsterdam, Netherlands) - 1 Sept 2024

Barsouk Adam, Elghawy Omar, Heidlauf Alec, Yu Connie, Wang Lucy, Yang David, Kurian Martin, Goel Keshav, Rushkin Lynn, Anran Huang Anna, Reed-Guy Lauren, Bleiberg Benjamin, Sun Lova, Singh Aditi, Cohen Roger B, Aggarwal Charu, Marmarelis Melina, Langer Corey

Abstract excerpt

OBJECTIVES: Limited data are available comparing the efficacy of osi versus earlier generation TKIs for mNSCLC with atypical EGFR mutations (AMs) such as L861Q, G719X, S768I and exon20. METHODS: We performed a single-institution retrospective analysis of patients with EGFR-mutated mNSCLC treated from 2007 to 2023 with 1L TKIs, comparing outcomes for AM patients treated with osi, afatinib, and erlotinib. Baseline...

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PMID: 39137595
DOI: 10.1016/j.lungcan.2024.107926

Genes

EGFR

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