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Generation of a human induced pluripotent stem cell line ZZUNEUi030-A from a female patient carrying a heterozygous CALM2 (c.395 A > T) mutation.

Stem cell research - 1 Dec 2024

Hua Chongpei, Sun Wenrui, Zhang Chunjin, Tian Xiaoxu, Qin Xintong, Dong Jianzeng, Li Xiaowei

Abstract excerpt

Calmodulin mutations can cause life-threatening long QT syndrome involving CALM1, CALM2, and CALM3. In this study, human induced pluripotent stem cells ZZUNEUi030-A were derived from a female patient with heterozygous CALM2 gene c. 395A → T by Sendai virus non-integrated reprogramming technology. The cell line showed a normal female karyotype (46, XX), expressed pluripotency markers, and had the ability to...

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PMID: 39137556
DOI: 10.1016/j.scr.2024.103515

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