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Clinical significance of germline breast cancer susceptibility gene (gBRCA) testing and olaparib as maintenance therapy for patients with pancreatic cancer.

BMC cancer - 12 Aug 2024

Kawamoto Yasuharu, Yamai Takuo, Ikezawa Kenji, Seiki Yusuke, Watsuji Ko, Hirao Takeru, Urabe Makiko, Kai Yugo, Takada Ryoji, Mukai Kaori, Nakabori Tasuku, Uehara Hiroyuki, Inoue Tazuko, Fujisawa Fumie, Ohkawa Kazuyoshi

Abstract excerpt

BACKGROUND: Germline breast cancer susceptibility gene (gBRCA) mutation in patients with pancreatic cancer (PC) is not common in clinical practice. Therefore, factors that efficiently show gBRCA mutations and the real-world outcomes of olaparib maintenance therapy have not been fully established. In the present study, we clarified the indicators for the effective detection of gBRCA mutation and the efficacy and...

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Identifiers

PMID: 39134950
DOI: 10.1186/s12885-024-12722-8
PMCID: PMC11321060

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