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The nonphototrophic hypocotyl 3 (NPH3) domain protein NRL5 is a trafficking-associated GTPase essential for drought resistance.

Science advances - 9 Aug 2024

Upadhyay-Tiwari Neha, Huang Xin-Jie, Lee Yi-Chen, Singh Shashi Kant, Hsu Chuan-Chi, Huang Shih-Shan, Verslues Paul E

Abstract excerpt

The mechanisms of plant drought resistance are unclear but may involve membrane trafficking and metabolic reprogramming, including proline accumulation. Forward genetic screening using a proline dehydrogenase 1 (ProDH1) promoter:reporter identified a drought hypersensitive mutant with a single-amino acid substitution (P335L) in the nonphototrophic hypocotyl 3 (NPH3) domain of NPH3/root phototropism 2-like 5...

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Identifiers

PMID: 39121213
DOI: 10.1126/sciadv.ado5429
PMCID: PMC11313873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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