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Article

Human induced pluripotent stem cells (NIHTVBi029-A and NIHTVBi030-A) generated from two patients with a heterozygous mutation in the CDC42 gene.

Stem cell research - 1 Oct 2024

Varea Isabella, Joseph Benjamin, Emmerich Kevin, Manohar-Sindhu Sahana, Zou Jizhong, Friend Kip, Tang Xuming, Yang Dan, de Jesus Rasheed Adriana A, Goldbach-Mansky Raphaela, Boehm Manfred

Abstract excerpt

Induced pluripotent stem cells (iPSCs) were successfully generated from peripheral blood mononuclear cells obtained from two patients with a heterozygous mutation in the CDC42 gene. Both iPSC lines expressed pluripotency markers, differentiated into the three germ layers in vitro, showed normal karyotypes, and retained the disease-causing mutation. Created iPSC lines and their differentiated derivatives may be of...

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Identifiers

PMID: 39106600
DOI: 10.1016/j.scr.2024.103517
PMCID: PMC11395911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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