Synergistic effects of novel penicillin-binding protein 1A amino acid substitutions contribute to high-level amoxicillin resistance of Helicobacter pylori.

doi:10.1128/msphere.00089-24

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Synergistic effects of novel penicillin-binding protein 1A amino acid substitutions contribute to high-level amoxicillin resistance of Helicobacter pylori.

mSphere - 28 Aug 2024

Cimuanga-Mukanya Alain, Tshibangu-Kabamba Evariste, Kisoko Patrick de Jesus Ngoma, Fauzia Kartika Afrida, Tshibangu Fabien Mbaya, Wola Antoine Tshimpi, Kashala Pascal Tshiamala, Ngoyi Dieudonné Mumba, Ahuka-Mundeke Steve, Revathi Gunturu, Disashi-Tumba Ghislain, Kido Yasutoshi, Matsumoto Takashi, Akada Junko, Yamaoka Yoshio

Abstract excerpt

The growing resistance to amoxicillin (AMX)-one of the main antibiotics used in Helicobacter pylori eradication therapy-is an increasing health concern. Several mutations of penicillin-binding protein 1A (PBP1A) are suspected of causing AMX resistance; however, only a limited set of these mutations have been experimentally explored. This study aimed to investigate four PBP1A mutations (i.e., T558S, N562H, T593A,...

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PMID: 39087788
DOI: 10.1128/msphere.00089-24
PMCID: PMC11351044

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