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Article

Use of bidirectional Mendelian randomization to unveil the association of Helicobacter pylori infection and autoimmune thyroid diseases

31 Jul 2024

Abstract excerpt

Previous observational studies found associations between Helicobacter pylori infection and autoimmune thyroid diseases (AITDs), but the causal nature of this association is still uncertain. We investigated the causal effect of six crucial antibodies against H. pylori on AITDs using a bidirectional Mendelian randomization (MR). We found that anti– H. pylori outer membrane protein (OMP) significantly increased the...

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PMID: 39083605
DOI: 10.1126/sciadv.adi8646

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