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Japanese encephalitis virus NS5 protein interacts with nucleolin to enhance the virus replication

30 Jul 2024

Abstract excerpt

ABSTRACT Japanese encephalitis virus (JEV) is an arthropod-borne, plus-strand flavivirus causing viral encephalitis in humans with a high case fatality rate. The JEV non-structural protein 5 (NS5) with the RNA-dependent RNA polymerase activity interacts with the viral and host proteins to constitute the replication complex. We have identified the multifunctional protein Nucleolin (NCL) as one of the several...

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PMID: 39078257
DOI: 10.1128/jvi.00858-24

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