Hepatectomy versus systemic therapy for liver-limited BRAF V600E-mutated colorectal liver metastases: multicentre retrospective study.

doi:10.1093/bjs/znae176

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Article

Hepatectomy versus systemic therapy for liver-limited BRAF V600E-mutated colorectal liver metastases: multicentre retrospective study.

The British journal of surgery - 2 Jul 2024

Margonis Georgios Antonios, Wang Jaeyun Jane, Boerner Thomas, Moretto Roberto, Buettner Stefan, Andreatos Nikolaos, Gagnière Johan, Wagner Doris, Løes Inger Marie, Bergamo Francesca, Pietrantonio Filippo, Scartozzi Mario, Spallanzani Andrea, Vincenzi Bruno, Antoniou Efstathios, Pikoulis Emmanouil, Sartore-Bianchi Andrea, Stasinos Georgios, Sasaki Kazunari, Pawlik Timothy M, Orlandi Armando, Pella Nicoletta, Fitschek Fabian, Kaczirek Klaus, Dupré Aurélien, Pozios Ioannis, Beyer Katharina, Kornprat Peter, Aucejo Federico N, Burkhart Richard, Weiss Matthew J, Lønning Per Eystein, Poultsides George, Cremolini Chiara, Kreis Martin E, D'Angelica Michael

Abstract excerpt

BACKGROUND: To date, only two studies have compared the outcomes of patients with liver-limited BRAF V600E-mutated colorectal liver metastases (CRLMs) managed with resection versus systemic therapy alone, and these have reported contradictory findings. METHODS: In this observational, international, multicentre study, patients with liver-limited BRAF V600E-mutated CRLMs treated with resection or systemic therapy...

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PMID: 39051667
DOI: 10.1093/bjs/znae176
PMCID: PMC11270119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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