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The GG genotype of rs743572 in CYP17A1 gene regulating the decrease of T/E ratio can be an independent risk factor for MetS-BPH: a retrospective cohort study.

World journal of urology - 24 Jul 2024

Chen Congcong, Pan Ningrui, Chen Zongping, Gou Chengren, He Xu, Wang Min, Chen Bo, Zhou Zidong, Ren Qixu, Zhong Youzhuang, Xiang You, Zhao Sicong, Yan Yong, Song Tao

Abstract excerpt

PURPOSE: To confirm if the CYP17A1 gene regulates the ratio of T/E leading to MetS-BPH. METHODS: 824 men, aged 47-88 years, were recruited into this study through consecutive routine physical examination programs and long-term outpatient screening. Several parameters, including SNPs of CYP17A1 gene, total testosterone, estradiol, and the ratio of total testosterone to estradiol (T/E) were obtained for each...

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PMID: 39046536
DOI: 10.1007/s00345-024-05138-3
PMCID: PMC11269469

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