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Article

Potential emergence of terbinafine resistance by squalene epoxidase gene mutations: An 18-month cohort study of onychomycosis patients in the United States.

Mycoses - 1 Jul 2024

Gupta Aditya K, Wang Tong, Polla Ravi Shruthi, Cooper Elizabeth A, Bamimore Mary A, Lincoln Sara A, Foreman Hui-Chen, Piguet Vincent, Bakotic Wayne L

Abstract excerpt

BACKGROUND: There is a concerning rise in antifungal-resistant dermatophytosis globally, with resistance to terbinafine conferred by point mutations in the squalene epoxidase (SQLE) gene. OBJECTIVES: Report changes in the prevalence and profile of SQLE mutations in onychomycosis patients in the United States. METHODS: A longitudinal cohort study of toenail samples was collected from suspected onychomycosis...

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PMID: 39036952
DOI: 10.1111/myc.13768

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