Article
Identification and prognostic analysis of metabolic genes associated with TP53 mutation in multiple myeloma.
Hematology (Amsterdam, Netherlands) - 1 Dec 2024
Tang Xiaoyan, Chen Yongping
Abstract excerpt
BACKGROUND: TP53 gene mutation is crucial in determining the prognosis of Multiple Myeloma (MM) patients. Understanding metabolic genes linked to TP53 mutation is vital for developing targeted therapies for these patients. METHOD: We analyzed The Cancer Genome Atlas (TCGA) dataset to identify genes related to TP53 mutation and metabolism. Using univariate Cox regression and protein-protein interaction (PPI)...
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