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Gut microbial factors predict disease severity in a mouse model of multiple sclerosis

15 Jul 2024

Abstract excerpt

Gut bacteria are linked to neurodegenerative diseases but the risk factors beyond microbiota composition are limited. Here we used a pre-clinical model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE), to identify microbial risk factors. Mice with different genotypes and complex microbiotas or six combinations of a synthetic human microbiota were analysed, resulting in varying...

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PMID: 39009690
DOI: 10.1038/s41564-024-01761-3

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