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Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

11 Sept 2017

Abstract excerpt

, an organism shown to induce a protective immunoregulatory profile in vitro. Immune cells from mouse recipients of MS-twin samples produced less IL-10 than immune cells from mice colonized with healthy-twin samples. IL-10 may have a regulatory role in spontaneous CNS autoimmunity, as neutralization of the cytokine in mice colonized with healthy-twin fecal samples increased disease incidence. These findings...

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PMID: 28893994
DOI: 10.1073/pnas.1711233114

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