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DropBlot: single-cell western blotting of chemically fixed cancer cells

13 Jul 2024

Abstract excerpt

Archived patient-derived tissue specimens play a central role in understanding disease and developing therapies. To address specificity and sensitivity shortcomings of existing single-cell resolution proteoform analysis tools, we introduce a hybrid microfluidic platform (DropBlot) designed for proteoform analyses in chemically fixed single cells. DropBlot serially integrates droplet-based encapsulation and lysis...

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PMID: 39003254
DOI: 10.1038/s41467-024-50046-0

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