Article
Use of a new DNA intercalating fluorescing probe for studies on the mechanism of frameshift mutagenesis in Salmonella typhimurium.
Biochimie - 1 Jan 2000
René B, Banoun H, Auclair C, Paoletti C
Abstract excerpt
As a general rule, ellipticine derivatives are mutagenic and intercalate into double-stranded nucleic acids. We have tested a new fluorescent ellipticine compound, 10[(1-carboxy-2-methylpropylidene)-amino]-9-hydroxy-2-methylell ipticinium (val-NMHE), for establishing the relationship between the amount of drug bound to nucleic acids in situ in Salmonella typhimurium and its biological effects: decrease of growth...
Topics
- Alkaloids
- DNA, Bacterial
- Ellipticines
- Fluorescent Dyes
- Intercalating Agents
- Mutagenicity Tests
- Mutation
- Salmonella typhimurium
- Spectrometry, Fluorescence