Asymptomatic herpes simplex virus brain infection elicits cellular senescence phenotypes in the central nervous system of mice suffering multiple sclerosis-like disease.

doi:10.1038/s42003-024-06486-x

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Asymptomatic herpes simplex virus brain infection elicits cellular senescence phenotypes in the central nervous system of mice suffering multiple sclerosis-like disease.

Communications biology - 4 Jul 2024

Duarte Luisa F, Villalobos Verónica, Farías Mónica A, Rangel-Ramírez Ma Andreina, González-Madrid Enrique, Navarro Areli J, Carbone-Schellman Javier, Domínguez Angélica, Alvarez Alejandra, Riedel Claudia A, Bueno Susan M, Kalergis Alexis M, Cáceres Mónica, González Pablo A

Abstract excerpt

Experimental autoimmune encephalomyelitis (EAE) is a demyelinating disease affecting the central nervous system (CNS) in animals that parallels several clinical and molecular traits of multiple sclerosis in humans. Herpes simplex virus type 1 (HSV-1) infection mainly causes cold sores and eye diseases, yet eventually, it can also reach the CNS, leading to acute encephalitis. Notably, a significant proportion of...

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Asymptomatic herpes simplex virus brain infection elicits cellular senescence phenotypes in the central nervous system of mice suffering multiple sclerosis-like disease.

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