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Phase 1/2 trials of human bone marrow–derived clonal mesenchymal stem cells for treatment of adults with moderate to severe atopic dermatitis

27 Jun 2024

Abstract excerpt

Background Mesenchymal stem cells (MSCs) play important roles in therapeutic applications by regulating immune responses. Objective We investigated the safety and efficacy of allogenic human bone marrow–derived clonal MSCs (hcMSCs) in subjects with moderate to severe atopic dermatitis (AD). Methods The study included a phase 1 open-label trial followed by a phase 2 randomized, double-blind, placebo-controlled...

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PMID: 38944393
DOI: 10.1016/j.jaci.2024.06.013

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