PLAG1-Rearranged Uterine Sarcomas: A Study of 11 Cases Showing a Wide Phenotypical Spectrum Not Limited to Myxoid Leiomyosarcoma-Like Morphology.

doi:10.1016/j.modpat.2024.100552

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Article

PLAG1-Rearranged Uterine Sarcomas: A Study of 11 Cases Showing a Wide Phenotypical Spectrum Not Limited to Myxoid Leiomyosarcoma-Like Morphology.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2024

Michal Michael, Agaimy Abbas, Croce Sabrina, Mechtersheimer Gunhild, Gross John M, Xing Deyin, Bell Debra A, Gupta Sounak, Mosaieby Elaheh, Martínek Petr, Klubíčková Natálie, Michalová Květoslava, Bouda Jiří, Fínek Jindřich, Hernandez Tahyna, Michal Michal, Schoolmeester J Kenneth, Ondič Ondrej

Abstract excerpt

PLAG1 gene fusions were recently identified in a subset of uterine myxoid leiomyosarcomas (M-LMS). However, we have encountered cases of PLAG1-rearranged uterine sarcomas lacking M-LMS-like morphology and/or any expression of smooth muscle markers. To better characterize their clinicopathologic features, we performed a multiinstitutional search that yielded 11 cases. The patients ranged in age from 34 to 72 years...

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Identifiers

PMID: 38942115
DOI: 10.1016/j.modpat.2024.100552

Genes

PLAG1
CD44
CHCHD7
FRMD6
MYOCD
PTK2
PUM1
TRPS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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