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Pangenome comparison of Bacteroides fragilis genomospecies unveils genetic diversity and ecological insights.

mSystems - 23 Jul 2024

Oles Renee E, Carrillo Terrazas Marvic, Loomis Luke R, Hsu Chia-Yun, Tribelhorn Caitlin, Belda-Ferre Pedro, Ea Allison C, Bryant MacKenzie, Young Jocelyn A, Carrow Hannah C, Sandborn William J, Dulai Parambir S, Sivagnanam Mamata, Pride David, Knight Rob, Chu Hiutung

Abstract excerpt

Bacteroides fragilis is a Gram-negative commensal bacterium commonly found in the human colon, which differentiates into two genomospecies termed divisions I and II. Through a comprehensive collection of 694 B. fragilis whole genome sequences, we identify novel features distinguishing these divisions. Our study reveals a distinct geographic distribution with division I strains predominantly found in North America...

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Identifiers

PMID: 38934546
DOI: 10.1128/msystems.00516-24
PMCID: PMC11265264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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