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Article

Pangenomes of human gut microbiota uncover links between genetic diversity and stress response.

Cell host & microbe - 9 Oct 2024

Shoer Saar, Reicher Lee, Zhao Chunyu, Pollard Katherine S, Pilpel Yitzhak, Segal Eran

Abstract excerpt

The genetic diversity of the gut microbiota has a central role in host health. Here, we created pangenomes for 728 human gut prokaryotic species, quadrupling the genes of strain-specific genomes. Each of these species has a core set of a thousand genes, differing even between closely related species, and an accessory set of genes unique to the different strains. Functional analysis shows high strain variability...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39353429
DOI: 10.1016/j.chom.2024.08.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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