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Article

High-dose furmonertinib combined with intraventricular chemotherapy as salvage therapy for leptomeningeal metastasis from EGFR exon 20 insertion-mutated lung cancer.

Journal of neuro-oncology - 1 Aug 2024

Yu Chuanyong, Xu Ting, Fang Hehui, Wang Xiaoyue, Liu Na, Yang Liangfeng, Fang Shencun

Abstract excerpt

PURPOSE: The treatment of leptomeningeal metastasis (LM), a serious complication of advanced non-small cell lung cancer (NSCLC), presents challenges, particularly in patients with EGFR exon 20 insertion (ex20ins) mutations. METHODS: This study retrospectively analyzed data from 10 EGFR ex20ins-mutated NSCLC patients with LM admitted at our institution from May 2011 to June 2023. Circulating tumor DNA (ctDNA) from...

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Identifiers

PMID: 38916849
DOI: 10.1007/s11060-024-04716-0

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