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Article

Furmonertinib combined with bevacizumab in EGFR-TKI-resistant leptomeningeal metastasis: analysis of the CSF ctDNA molecular response and survival outcomes.

British journal of cancer - 1 Jun 2026

Wang Xiaoyue, Xie Yuwen, Hu Jin, Liu Na, Yang Liangfeng, Xu Ting, Xu Shu, Yu Chuanyong, Fang Shencun

Abstract excerpt

BACKGROUND: Leptomeningeal metastasis (LM) after the development of third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance is indicative of a poor prognosis in EGFR-mutant non-small cell lung cancer (NSCLC), and no standardised treatments are currently available. The aims of this study were to evaluate the outcomes of combination therapy with bevacizumab plus high-dose...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41942607
DOI: 10.1038/s41416-026-03407-z
PMCID: PMC13184092

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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