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T2DM/CKD genetic risk scores and the progression of diabetic kidney disease in T2DM subjects.

Gene - 15 Nov 2024

Galuška David, Pácal Lukáš, Chalásová Katarína, Divácká Petra, Řehořová Jitka, Svojanovský Jan, Hubáček Jaroslav A, Lánská Věra, Kaňková Kateřina

Abstract excerpt

This study aimed at understanding the predictive potential of genetic risk scores (GRS) for diabetic kidney disease (DKD) progression in patients with type 2 diabetes mellitus (T2DM) and Major Cardiovascular Events (MCVE) and All-Cause Mortality (ACM) as secondary outcomes. We evaluated 30 T2DM and CKD GWAS-derived single nucleotide polymorphisms (SNPs) and their association with clinical outcomes in a central...

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PMID: 38909968
DOI: 10.1016/j.gene.2024.148724

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