Article
Ceftazidime/avibactam resistance is associated with PER-3-producing ST309 lineage in Chilean clinical isolates of non-carbapenemase producing Pseudomonas aeruginosa.
Frontiers in cellular and infection microbiology - 1 Jan 2024
Soto Katherine D, Alcalde-Rico Manuel, Ugalde Juan A, Olivares-Pacheco Jorge, Quiroz Valeria, Brito Bárbara, Rivas Lina M, Munita José M, García Patricia C, Wozniak Aniela
Abstract excerpt
Introduction: Ceftazidime/avibactam (CZA) is indicated against multidrug-resistant Pseudomonas aeruginosa, particularly those that are carbapenem resistant. CZA resistance in P. aeruginosa producing PER, a class A extended-spectrum β-lactamase, has been well documented in vitro. However, data regarding clinical isolates are scarce. Our aim was to analyze the contribution of PER to CZA resistance in...
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