Multiomic analysis identifies a high-risk signature that predicts early clinical failure in DLBCL.

doi:10.1038/s41408-024-01080-0

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Article

Multiomic analysis identifies a high-risk signature that predicts early clinical failure in DLBCL.

Blood cancer journal - 20 Jun 2024

Wenzl Kerstin, Stokes Matthew E, Novak Joseph P, Bock Allison M, Khan Sana, Hopper Melissa A, Krull Jordan E, Dropik Abigail R, Walker Janek S, Sarangi Vivekananda, Mwangi Raphael, Ortiz Maria, Stong Nicholas, Huang C Chris, Maurer Matthew J, Rimsza Lisa, Link Brian K, Slager Susan L, Asmann Yan, Mondello Patrizia, Morin Ryan, Ansell Stephen M, Habermann Thomas M, Witzig Thomas E, Feldman Andrew L, King Rebecca L, Nowakowski Grzegorz, Cerhan James R, Gandhi Anita K, Novak Anne J

Abstract excerpt

Recent genetic and molecular classification of DLBCL has advanced our knowledge of disease biology, yet were not designed to predict early events and guide anticipatory selection of novel therapies. To address this unmet need, we used an integrative multiomic approach to identify a signature at diagnosis that will identify DLBCL at high risk of early clinical failure. Tumor biopsies from 444 newly diagnosed DLBCL...

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PMID: 38902256
DOI: 10.1038/s41408-024-01080-0
PMCID: PMC11189905

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