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A Polynesian-specific SLC22A3 variant associates with low plasma lipoprotein(a) concentrations independent of apo(a) isoform size in males.

Bioscience reports - 31 Jul 2024

Wang Qian, McCormick Sally, Leask Megan P, Watson Huti, O'Sullivan Conor, Krebs Jeremy D, Hall Rosemary, Whitfield Patricia, Merry Troy L, Murphy Rinki, Shepherd Peter R

Abstract excerpt

Lipoprotein(a) (Lp(a)) is a low-density lipoprotein (LDL)-like particle in which the apolipoprotein B component is covalently linked to apolipoprotein(a) (apo(a)). Lp(a) is a well-established independent risk factor for cardiovascular diseases. Plasma Lp(a) concentrations vary enormously between individuals and ethnic groups. Several nucleotide polymorphisms in the SLC22A3 gene associate with Lp(a) concentration...

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PMID: 38896441
DOI: 10.1042/BSR20240403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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