Article
Genome-wide association studies in Samoans give insight into the genetic architecture of fasting serum lipid levels.
Journal of human genetics - 1 Feb 2021
Carlson Jenna C, Weeks Daniel E, Hawley Nicola L, Sun Guangyun, Cheng Hong, Naseri Take, Reupena Muagututi'a Sefuiva, Tuitele John, Deka Ranjan, McGarvey Stephen T, Minster Ryan L
Abstract excerpt
The current understanding of the genetic architecture of lipids has largely come from genome-wide association studies (GWAS). To date, few GWAS have examined the genetic architecture of lipids in Polynesians, and none have in Samoans, whose unique population history, including many population bottlenecks, may provide insight into the biological foundations of variation in lipid levels. Here we performed a GWAS of...
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