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Article

Successful Immune Reconstitution in a Patient with a TYK2 Deficiency after Allogeneic Stem Cell Transplantation from Unrelated Donors.

Journal of clinical immunology - 19 Jun 2024

Gao Yelei, Wang Ya, Zhou Lina, Lv Ge, Yu Jie, Zhang Luying, Meng Yan, He Wenli, Chen Ran, Zhao Xiaodong, Dou Ying

Abstract excerpt

A boy with primary immunodeficiency, caused by a tyrosine kinase 2 (TYK2) mutation, presented with immune defects and a lifelong history of severe infections. Our aim was to determine whether allogeneic hematopoietic stem cell transplantation (HSCT) could restore the patient's immune defenses and reduce susceptibility to infection. In the absence of a suitable HLA-matched blood relative to act as a donor, the...

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Source

Identifiers

PMID: 38896258
DOI: 10.1007/s10875-024-01753-2

Genes

TYK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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