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Article

Identification and development of Tetra-ARMS PCR-based screening test for a genetic variant of OLA1 (Tyr254Cys) in the human failing heart.

PloS one - 1 Jan 2024

Dubey Praveen K, Dubey Shubham, Singh Sarojini, Bhat Purnima Devaki, Pogwizd Steven, Krishnamurthy Prasanna

Abstract excerpt

Obg-like ATPase 1 (OLA1) protein has GTP and ATP hydrolyzing activities and is important for cellular growth and survival. The human OLA1 gene maps to chromosome 2 (locus 2q31.1), near Titin (TTN), which is associated with familial dilated cardiomyopathy (DCM). In this study, we found that expression of OLA1 was significantly downregulated in failing human heart tissue (HF) compared to non-failing hearts (NF)....

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Topics

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Share to Adenosine Triphosphatases
Share to Cardiomyopathy, Dilated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Testing

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Share to Heart Failure

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Share to Polymerase Chain Reaction

Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 38889130
DOI: 10.1371/journal.pone.0293105
PMCID: PMC11185490

Genes

OLA1
TTN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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