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Variations in the LINGO2 and GLIS3 Genes and Gene-Environment Interactions Increase Gestational Diabetes Mellitus Risk in Chinese Women.

Environmental science & technology - 2 Jul 2024

Huang Xiao, Liang Weiwei, Yang Runqiu, Jin Lei, Zhao Kai, Chen Juan, Shang Xuejun, Zhou Yuanzhong, Wang Xin, Yu Hongsong

Abstract excerpt

Gestational diabetes mellitus (GDM) has been found to be a common complication in pregnant women, known to escalate the risk of negative obstetric outcomes. In our study, we genotyped 1,566 Chinese pregnant women for two single nucleotide polymorphisms (SNPs) in the LINGO2 gene and one SNP in the GLIS3 gene, utilizing targeted next-generation sequencing. The impact of two interacting genes, and the interaction of...

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Identifiers

PMID: 38888423
DOI: 10.1021/acs.est.4c03221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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