Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women.

doi:10.1038/s10038-025-01330-4

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Article

Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women.

Journal of human genetics - 1 May 2025

Kawahara Tomoki, Nawa Nobutoshi, Murakami Keiko, Tanaka Toshihiro, Ohseto Hisashi, Takahashi Ippei, Narita Akira, Obara Taku, Ishikuro Mami, Orui Masatsugu, Noda Aoi, Shinoda Genki, Nagata Yuki, Nagaie Satoshi, Ogishima Soichi, Sugawara Junichi, Kure Shigeo, Kinoshita Kengo, Hozawa Atsushi, Fuse Nobuo, Tamiya Gen, Bennett Wendy L, Taub Margaret A, Surkan Pamela J, Kuriyama Shinichi, Fujiwara Takeo

Abstract excerpt

Gestational diabetes mellitus (GDM) is common in Japanese women, posing serious risks to mothers and offspring. This study investigated the influence of maternal genotypes on the risk of GDM and examined how these genotypes modify the effects of psychological and dietary factors during pregnancy. We analyzed data from 20,399 women in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort. Utilizing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40119124
DOI: 10.1038/s10038-025-01330-4
PMCID: PMC12032887

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