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Article

Distal mutations enhance efficiency of free and immobilized NOV1 dioxygenase for vanillin synthesis.

Journal of biotechnology - 10 Aug 2024

De Simone Mario, Alonso-Cotchico Lur, Lucas Maria Fátima, Brissos Vânia, Martins Lígia O

Abstract excerpt

Protein engineering is crucial to improve enzymes' efficiency and robustness for industrial biocatalysis. NOV1 is a bacterial dioxygenase that holds biotechnological potential by catalyzing the one-step oxidation of the lignin-derived isoeugenol into vanillin, a popular flavoring agent used in food, cleaning products, cosmetics and pharmaceuticals. This study aims to enhance NOV1 activity and operational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38880386
DOI: 10.1016/j.jbiotec.2024.06.012

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