Spindle Cell Lesions with Oncogenic EGFR Kinase Domain Aberrations: Expanding the Spectrum of Protein Kinase-Related Mesenchymal Tumors.

doi:10.1016/j.modpat.2024.100539

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Article

Spindle Cell Lesions with Oncogenic EGFR Kinase Domain Aberrations: Expanding the Spectrum of Protein Kinase-Related Mesenchymal Tumors.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2024

Vallese Silvia, Barresi Sabina, Hiemcke-Jiwa Laura, Patrizi Sara, Kester Lennart, Giovannoni Isabella, Cardoni Antonello, Pedace Lucia, Nardini Claudia, Tancredi Chantal, Desideri Martina, von Deimling Andreas, Mura Rosa M, Piga Michela, Errico Maria E, Stracuzzi Alessandra, Alaggio Rita, Miele Evelina, Flucke Uta

Abstract excerpt

EGFR aberrations are reported in a subset of myofibroblastic lesions with kinase domain duplication (EGFR-KDD) and exon 20 mutations being assigned to infantile fibrosarcomas (IFS), mesoblastic nephroma, and fibrous hamartoma of infancy (FHI), respectively. In this retrospective study, we correlated molecular findings with the histomorphology of 14 myofibroblastic lesions harboring such genetic changes identified...

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PMID: 38880352
DOI: 10.1016/j.modpat.2024.100539

Genes

EGFR
CD34

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