Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mesenchymal neoplasms with RAF/BRAF alterations: eight cases revealing novel fusions, V600E mutation and clonal evolution.

Journal of clinical pathology - 20 Aug 2026

Feng Xiaolong, Huang Xianming, Hao Weiwei, Wei Jiacong, Liu Xiaoqi, Wen Yaru, Cao Qi, Jiang Yulu, Gong Lihua

Abstract excerpt

OBJECTIVE: While kinase-altered spindle cell tumours were classically recognised in paediatric superficial soft tissues, recent literature indicates an expanding clinicopathologic spectrum. This study investigates a cohort of RAF/BRAF-altered mesenchymal tumours to further characterise their presentations in adults, deep-seated/visceral locations, variable immunophenotypes and complex molecular evolution....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to CD34 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Fusion

Share to Immunohistochemistry

Share to Mutation

Share to Proto-Oncogene Proteins B-raf

Share to Soft Tissue Neoplasms

Share to Young Adult

Source

Identifiers

PMID: 42236131
DOI: 10.1136/jcp-2026-210784

Genes

BRAF
CD34
IQSEC1
NTRK1
PLEKHH3
PTEN
RAF1
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mesenchymal neoplasms with RAF/BRAF alterations: eight cases revealing novel fusions, V600E mutation and clonal evolution.PMID 42236131Read ↗

Recurrent BRAF Gene Fusions in a Subset of Pediatric Spindle Cell SarcomasSemantic proximity Read ↗

EWSR1::ATF1 fusions characterize a group of extra-abdominal epithelioid and round cell mesenchymal neoplasms, phenotypically overlapping with sclerosing epithelioid fibrosarcomas, and intra-abdominal FET::CREB fusion neoplasms.Semantic proximity Read ↗

Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern.Semantic proximity Read ↗

Back to the future! Selected bone and soft tissue neoplasms with shared genetic alterations but differing morphological and immunohistochemical phenotypes.Semantic proximity Read ↗

A morphologic and molecular reappraisal of myoepithelial tumors of soft tissue, bone, and viscera with EWSR1 and FUS gene rearrangements.Semantic proximity Read ↗

Pathology of soft tissue sarcomas.Semantic proximity Read ↗

Spindle Cell Lesions with Oncogenic EGFR Kinase Domain Aberrations: Expanding the Spectrum of Protein Kinase-Related Mesenchymal Tumors.Semantic proximity Read ↗

New advances in the molecular classification of pediatric mesenchymal tumorsSemantic proximity Read ↗

EWSR1-PATZ1-rearranged sarcoma: a report of nine cases of spindle and round cell neoplasms with predilection for thoracoabdominal soft tissues and frequent expression of neural and skeletal muscle markers.Semantic proximity Read ↗

Molecular pathology in sarcomas.Semantic proximity Read ↗

[Sarcomas: from pathology to molecular pathology and new nosology].Semantic proximity Read ↗

TFG::MET ‐rearranged soft tissue tumor: A rare infantile neoplasm with a distinct low‐grade triphasic morphologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.