Immunogenicity and protection efficacy of a COVID-19 DNA vaccine encoding spike protein with D614G mutation and optimization of large-scale DNA vaccine production.

doi:10.1038/s41598-024-64690-5

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Immunogenicity and protection efficacy of a COVID-19 DNA vaccine encoding spike protein with D614G mutation and optimization of large-scale DNA vaccine production.

Scientific reports - 15 Jun 2024

Gül Aytül, Erkunt Alak Sedef, Can Hüseyin, Karakavuk Muhammet, Korukluoğlu Gülay, Altaş Ayşe Başak, Gül Ceren, Karakavuk Tuğba, Köseoğlu Ahmet Efe, Ülbeği Polat Hivda, Yazıcı Malkoçoğlu Hilal, Taş Ekiz Arzu, Abacı İrem, Aksoy Özge, Enül Hakan, Adıay Cumhur, Uzar Serdar, Saraç Fahriye, Ün Cemal, Gürüz Adnan Yüksel, Kantarcı Ayşe Gülten, Akbaba Hasan, Erel Akbaba Gülşah, Yılmaz Habibe, Değirmenci Döşkaya Aysu, Taşbakan Meltem, Pullukçu Hüsnü, Karasulu Ercüment, Tekin Şaban, Döşkaya Mert

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 had devastating consequences for human health. Despite the introduction of several vaccines, COVID-19 continues to pose a serious health risk due to emerging variants of concern. DNA vaccines gained importance during the pandemic due to their advantages such as induction of both arms of immune response, rapid development, stability, and safety profiles. Here, we...

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Identifiers

PMID: 38879684
DOI: 10.1038/s41598-024-64690-5
PMCID: PMC11180131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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