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Targeted silencing of SOCS1 by DNMT1 promotes stemness of human liver cancer stem-like cells

12 Jun 2024

Abstract excerpt

BACKGROUND: Human liver cancer stem-like cells (HLCSLCs) are widely acknowledged as significant factors in the recurrence and eradication of hepatocellular carcinoma (HCC). The sustenance of HLCSLCs' stemness is hypothesized to be intricately linked to the epigenetic process of DNA methylation modification of genes associated with anticancer properties. The present study aimed to elucidate the...

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PMID: 38867242
DOI: 10.1186/s12935-024-03322-4

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