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Article

Brain reserve in midlife is associated with executive function changes across 12 years.

Neurobiology of aging - 1 Sept 2024

Gustavson Daniel E, Elman Jeremy A, Reynolds Chandra A, Eyler Lisa T, Fennema-Notestine Christine, Puckett Olivia K, Panizzon Matthew S, Gillespie Nathan A, Neale Michael C, Lyons Michael J, Franz Carol E, Kremen William S

Abstract excerpt

We examined how brain reserve in midlife, measured by brain-predicted age difference scores (Brain-PADs), predicted executive function concurrently and longitudinally into early old age, and whether these associations were moderated by young adult cognitive reserve or APOE genotype. 508 men in the Vietnam Era Twin Study of Aging (VETSA) completed neuroimaging assessments at mean age 56 and six executive function...

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Identifiers

PMID: 38852544
DOI: 10.1016/j.neurobiolaging.2024.05.001
PMCID: PMC11246793

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