Article
Generation of single-round infectious rotavirus with a mutation in the intermediate capsid protein VP6.
Journal of virology - 23 Jul 2024
Kotaki Tomohiro, Kanai Yuta, Onishi Megumi, Minami Shohei, Chen Zelin, Nouda Ryotaro, Nurdin Jeffery A, Yamasaki Moeko, Kobayashi Takeshi
Abstract excerpt
Rotavirus causes severe diarrhea in infants. Although live attenuated rotavirus vaccines are available, vaccine-derived infections have been reported, which warrants development of next-generation rotavirus vaccines. A single-round infectious virus is a promising vaccine platform; however, this platform has not been studied extensively in the context of rotavirus. Here, we aimed to develop a single-round...
Topics
- Capsid Proteins
- Rotavirus
- Animals
- Antigens, Viral
- Mice
- Rotavirus Infections
- Rotavirus Vaccines
- Humans
- Mutation
- Antibodies, Viral
- Antibodies, Neutralizing
- Mice, Inbred BALB C
- Cell Line
- Vaccines, Attenuated