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Hemophagocytic Lymphohistiocytosis Gene Variants in Severe Aplastic Anemia and Their Impact on Hematopoietic Cell Transplantation Outcomes.

Transplantation and cellular therapy - 1 Aug 2024

Rafati Maryam, McReynolds Lisa J, Wang Youjin, Hicks Belynda, Jones Kristine, Spellman Stephen R, He Meilun, Bolon Yung-Tsi, Arrieta-Bolaños Esteban, Saultz Jennifer N, Lee Stephanie J, Savage Sharon A, Gadalla Shahinaz M

Abstract excerpt

Germline genetic testing for patients with severe aplastic anemia (SAA) is recommended to guide treatment, including the use of immunosuppressive therapy and/or adjustment of hematopoietic cell transplantation (HCT) modalities. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory condition often associated with cytopenias with autosomal recessive (AR) or X-linked recessive (XLR)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38810947
DOI: 10.1016/j.jtct.2024.05.017
PMCID: PMC11296907

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