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Targeting ARNT attenuates chemoresistance through destabilizing p38α-MAPK signaling in glioblastoma

28 May 2024

Abstract excerpt

Glioblastoma (GBM) is the most aggressive and lethal brain tumor in adults. This study aimed to investigate the functional significance of aryl hydrocarbon receptor nuclear translocator (ARNT) in the pathogenesis of GBM. Analysis of public datasets revealed ARNT is upregulated in GBM tissues compared to lower grade gliomas or normal brain tissues. Higher ARNT expression correlated with the mesenchymal subtype and...

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PMID: 38806469
DOI: 10.1038/s41419-024-06735-1

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