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Article

Multiple UDP glycosyltransferases modulate benzimidazole drug sensitivity in the nematode Caenorhabditis elegans in an additive manner.

International journal for parasitology - 1 Sept 2024

Sharma Nidhi, Au Vinci, Martin Kiana, Edgley Mark L, Moerman Don, Mains Paul E, Gilleard John S

Abstract excerpt

Xenobiotic biotransformation is an important modulator of anthelmintic drug potency and a potential mechanism of anthelmintic resistance. Both the free-living nematode Caenorhabditis elegans and the ruminant parasite Haemonchus contortus biotransform benzimidazole drugs by glucose conjugation, likely catalysed by UDP-glycosyltransferase (UGT) enzymes. To identify C. elegans genes involved in benzimidazole drug...

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PMID: 38806068
DOI: 10.1016/j.ijpara.2024.05.003

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