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Runx2 and Polycystins in Bone Mechanotransduction: Challenges for Therapeutic Opportunities

13 May 2024

Abstract excerpt

Bone mechanotransduction is a critical process during skeletal development in embryogenesis and organogenesis. At the same time, the type and level of mechanical loading regulates bone remodeling throughout the adult life. The aberrant mechanosensing of bone cells has been implicated in the development and progression of bone loss disorders, but also in the bone-specific aspect of other clinical entities, such as...

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PMID: 38791330
DOI: 10.3390/ijms25105291

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