Article
Quantitative radiomics and qualitative LI-RADS imaging descriptors for non-invasive assessment of β-catenin mutation status in hepatocellular carcinoma.
Abdominal radiology (New York) - 1 Jul 2024
Arefan Dooman, D'Ardenne Nicholas M, Iranpour Negaur, Catania Roberta, Yousef Jacob, Chupetlovska Kalina, Moghe Akshata, Sholosh Biatta, Thangasamy Senthur, Borhani Amir A, Singhi Aatur D, Monga Satdarshan P, Furlan Alessandro, Wu Shandong
Abstract excerpt
PURPOSE: Gain-of-function mutations in CTNNB1, gene encoding for β-catenin, are observed in 25-30% of hepatocellular carcinomas (HCCs). Recent studies have shown β-catenin activation to have distinct roles in HCC susceptibility to mTOR inhibitors and resistance to immunotherapy. Our goal was to develop and test a computational imaging-based model to non-invasively assess β-catenin activation in HCC, since liver...
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