Article
Revisiting the gene mutations and protein profile of WT 9-12: An autosomal dominant polycystic kidney disease cell line.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 2024
Chai Hwa Chia, Mahendran Rhubaniya, Ong Kien Chai, Chua Kek Heng
Abstract excerpt
WT 9-12 is one of the cell lines commonly used for autosomal dominant polycystic kidney disease (ADPKD) studies. Previous studies had described the PKD gene mutations and polycystin expression in WT 9-12. Nonetheless, the mutations occurring in other ADPKD-associated genes have not been investigated. This study aims to revisit these mutations and protein profile of WT 9-12. Whole genome sequencing verified the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.