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Article

Endothelial to mesenchymal Notch signaling regulates skeletal repair

23 May 2024

Abstract excerpt

We present a transcriptomic analysis that provides a better understanding of regulatory mechanisms within the healthy and injured periosteum. The focus of this work is on characterizing early events controlling bone healing during formation of periosteal callus on day 3 after fracture. Building on our previous findings showing that induced Notch1 signaling in osteoprogenitors leads to better healing, we compared...

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PMID: 38781018
DOI: 10.1172/jci.insight.181073

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