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Isolation and phenotypic characterization of cancer stem cells from metastatic oral cancer cells.

Oral diseases - 1 Nov 2024

Aquino Iara Gonçalves, Cuadra-Zelaya Florence Juana Maria, Bizeli Ana Laura Valença, Palma Patricia Vianna Bonini, Mariano Fernanda Viviane, Salo Tuula, Coletta Ricardo Della, Bastos Débora Campanella, Graner Edgard

Abstract excerpt

OBJECTIVES: To isolate cancer stem cells (CSC) from a metastatic oral squamous cell carcinoma (OSCC) cell line and investigate their in vitro and in vivo phenotypic characteristics. MATERIALS AND METHODS: Subpopulations with individual staining intensities for CD44 and CD326 were isolated from the OSCC cell line LN-1A by FACS: CD44Low/CD326- (CSC-M1), CD44Low/CD326High (CSC-E), and CD44High/CD326- (CSC-M2)....

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PMID: 38764396
DOI: 10.1111/odi.15003

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